co-transplantation of schwann and bone marrow stromal cells promotes locomotor recovery in the rat contusion model of spinal cord injury
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Transplanting P75-Suppressed Bone Marrow Stromal Cells Promotes Functional Behavior in a Rat Model of Spinal Cord Injury
Background: Bone marrow stromal cells (BMSC) have been successfully employed for movement deficit recovery in spinal cord injury (SCI) rat models. One of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. According to our previous studies, p75 receptor, known as the death receptor, is only expressed in BMSC in...
متن کاملEvaluation of the Functional Recovery in Sciatic Nerve Injury following the Co-transplantation of Schwann and Bone Marrow Stromal Stem Cells in Rat
Introduction: Transplantation of bone marrow stromal cells (BMSCs) or Schwann cells (SCs) can increase axonal regeneration in peripheral nerve injuries. Based on our previous investigations, the goal of the present work was to examine the individual and synergistic effects of the two different cell types in sciatic nerve injury . We pursued to evaluate the effects of BMSCs and SCs co-transplant...
متن کاملco- transplantation of bone marrow stromal cells with schwann cells evokes mechanical allodynia in the contusion model of spinal cord injury in rats
objective: several studies have shown that, although transplantation of neural stem cells into the contusion model of spinal cord injury (sci) promotes locomotor function and improves functional recovery, it induces a painful response, allodynia. different studies indicate that bone marrow stromal cells (bmscs) and schwann cells (scs) can improve locomotor recovery when transplanted into the in...
متن کاملCentral Neuropathic Pain After Graft of Bone Marrow Stromal Cells in the Spinal Cord Contusion of Rat
Purpose: The purpose of this study was the investigation of thermal and mechanical Allodynia after BMSCs grafting in the Spinal Cord Contusion of rat Materials and Methods: In this study used 40 female Sprague- Dawley 6-8 week old that 33 rats received vertebral laminectomy to expose spinal cord (L1 vertebral level). The cord was then contused with the weight drop device. Experimental groups c...
متن کاملComparison of human adipose-derived stem cells and chondroitinase ABC transplantation on locomotor recovery in the contusion model of spinal cord injury in rats
Objective(s):Spinal cord injury (SCI) is one of the most serious clinical diseases and its treatment has been a subject of interest to researchers. There are two important therapeutic strategies in the treatment of SCI: replacing lost tissue cells through cells implantation and scar elimination. Therefore, in this study we used human adipose-derived stem cells (hADSCs) implantation and injectio...
متن کاملImprovement of Spinal Cord Injury in Rat Model via Transplantation of Neural Stem Cells Derived From Bone Marrow
Abstract Background & Aims: Cell therapy is among the novel therapeutic methods effective in the treatment of spinal cord injuries. The aim of the present study was using neural stem cells (NSCs) in treating contusion spinal cord injury in rat model. Methods: Bone marrow stromal cells (BMSCs) were isolated from adult rats...
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عنوان ژورنال:
cell journalجلد ۱۲، شماره ۱، صفحات ۷-۱۶
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